Formulary
Carfilzomib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Carfilzomib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Carfilzomib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Carfilzomib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Multiple myeloma**
- **Adult** (By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Side effects
For carfilzomib [Specialist drug] Common or very common Anaemia; anxiety; appetite decreased; arrhythmias; arthralgia; asthenia; cataract; chest pain; chills; confusion; constipation; cough; decreased leucocytes; dehydration; diarrhoea; dizziness; dysphonia; dyspnoea; electrolyte imbalance; embolism and thrombosis; fever; flushing; gastrointestinal discomfort; haemorrhage; headache; heart failure; hyperbilirubinaemia; hyperglycaemia; hyperhidrosis; hypertension; hyperuricaemia; hypoalbuminaemia; hypotension; increased risk of infection; influenza like illness; infusion related reaction; insomnia; malaise; muscle complaints; muscle weakness; myocardial infarction; nausea; neutropenia; oropharyngeal pain; pain; palpitations; peripheral neuropathy; peripheral oedema; pulmonary hypertension; pulmonary oedema; renal impairment; respiratory disorders; sensation abnormal; sepsis; skin reactions; thrombocytopenia; tinnitus; toothache; vision blurred; vomiting Uncommon Cardiac arrest; cardiomyopathy; Clostridioides difficile colitis; gastrointestinal perforation; haemolytic uraemic syndrome; hepatic disorders; hepatitis B reactivation; interstitial lung disease; intracranial haemorrhage; multi organ failure; myocardial ischaemia; pericardial effusion; pericarditis; stroke; tumour lysis syndrome Rare or very rare Angioedema; posterior reversible encephalopathy syndrome (PRES); thrombotic microangiopathy Frequency not known Progressive multifocal leukoencephalopathy (PML); QT interval prolongation Side-effects, further information Progressive multifocal leukoencephalopathy (PML) Interrupt treatment if suspected and discontinue if confirmed. Thrombotic microangiopathy Thrombotic microangiopathy, including thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome, including fatal events, have been reported; interrupt treatment if suspected. Tumour lysis syndrome Tumour lysis syndrome, including fatal cases, have been reported; interrupt treatment if suspected.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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