Formulary
Caffeine Citrate: Indications, Dosing, Side Effects and Interactions
Caffeine Citrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Caffeine Citrate: Indications, Dosing, Side Effects and Interactions
Caffeine Citrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Neonatal apnoea (specialist supervision in hospital) for caffeine citrate**
- **Neonate** (By mouth, or by intravenous infusion): Loading dose 20 mg/kg, then maintenance 5 mg/kg once daily, started 24 hours after the loading dose; increased if necessary up to 20 mg/kg daily, a maintenance dose above 20 mg/kg daily can be considered if therapeutic efficacy is not achieved-the plasma-caffeine concentration should be monitored to ensure that a safe level is maintained.
Interactions
**Severe interactions:**
- Warfarin: The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
**Other interactions (21):**
- Aspirin, paracetamol and caffeine combination medicines should not be used together with other non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin and cyclo-oxygenase-2 specific...
- Particularly, treatment with aspirin should not be initiated within the first 24 hours after treatment with alteplase in acute stroke patients.
- Uricosurics (e.g.
- Loop diuretics (e.g.
- If a diuretic is administered simultaneously with aspirin, it is necessary to ensure adequate hydration of the patient and to monitor the kidney function and blood pressure, particularly when...
- Like other NSAIDs, concomitant use of aspirin with diuretics or antihypertensive agents (e.g., beta-blockers, angiotensin converting enzyme (ACE) inhibitors) may cause a decrease in their...
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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