Formulary
Cabozantinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Cabozantinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Cabozantinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Cabozantinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Medullary thyroid carcinoma**
- **Adult** (By Mouth Using Capsules): Specialist drug - access specialist resources for dosing information.
**Renal cell carcinoma,Hepatocellular carcinoma,Differentiated thyroid carcinoma**
- **Adult** (By Mouth Using Tablets): Specialist drug - access specialist resources for dosing information.
Contraindications
For cabozantinib [Specialist drug] Reversible posterior leukoencephalopathy syndrome
Side effects
For cabozantinib [Specialist drug] Common or very common Abscess; alopecia; anaemia; anxiety; appetite decreased; arrhythmias; arthralgia; asthenia; chills; cholelithiasis; confusion; constipation; cough; dehydration; depression; diarrhoea; dizziness; dry mouth; dysphagia; dysphonia; dyspnoea; dysuria; ear pain; electrolyte imbalance; embolism and thrombosis; encephalopathy; fistula; gastrointestinal discomfort; gastrointestinal disorders; haemorrhage; hair changes; headache; healing impaired; hyperbilirubinaemia; hyperglycaemia; hypertension; hypoalbuminaemia; hypoglycaemia; hypotension; hypothyroidism; increased risk of infection; lymphopenia; mucositis; muscle spasms; nausea; nerve disorders; neutropenia; oedema; oral disorders; oropharyngeal pain; osteonecrosis of jaw (discontinue); pain; pallor; pancreatitis; paraesthesia; peripheral coldness; proteinuria; respiratory disorders; skin reactions; stroke; taste altered; thrombocytopenia; tinnitus; tracheo-oesophageal fistula; tremor; vision blurred; vomiting; weight decreased Uncommon Abnormal dreams; amenorrhoea; angina pectoris; ataxia; cataract; concentration impaired; conjunctivitis; cyst; delirium; eosinophilia; hearing impairment; hepatic disorders; loss of consciousness; myocardial infarction; pneumonitis; renal impairment; rhabdomyolysis; seizure; skin ulcer; speech disorder; telangiectasia; throat oedema; thrombocytosis; wound complications Frequency not known Aneurysm; artery dissection; cutaneous vasculitis; QT interval prolongation Side-effects, further information Discontinue if nephrotic syndrome occurs. Hand and foot syndrome (palmar-plantar erythrodysaesthesia syndrome) Consider treatment interruption if severe and restart at a lower dose when resolved to grade 1. Haemorrhage Severe, sometimes fatal, haemorrhage has been reported-discontinue. Perforations and fistulas Discontinue if fistulas, such as gastrointestinal fistula, tracheal fistula, and tracheo-oesophageal fistula, or gastrointestinal perforation occurs. Thromboembolic events Discontinue if symptoms develop, including myocardial infarction or other significant thromboembolic complications. Wound Complications Discontinue if wound healing complications requiring medical intervention occur.
Medicinal forms
Tablet,Capsule
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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