Formulary
C1-esterase inhibitor: Indications, Dosing, Side Effects and Interactions
C1-esterase inhibitor clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
C1-esterase inhibitor: Indications, Dosing, Side Effects and Interactions
C1-esterase inhibitor clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Acute attacks of hereditary angioedema (under expert supervision)**
- **Adult** (By Slow Intravenous Injection): 1000 units for 1 dose, dose may be repeated if necessary after 60 minutes (or sooner for patients experiencing laryngeal attacks or if treatment initiation is delayed).
**Short-term prophylaxis of hereditary angioedema before dental, medical, or surgical procedures (under expert supervision)**
- **Adult** (By Slow Intravenous Injection): 1000 units for 1 dose, to be administered up to 24 hours before procedure.
**Long-term prophylaxis of severe, recurrent attacks of hereditary angioedema where acute treatment is inadequate, or when oral prophylaxis is inadequate or not tolerated (under expert supervision)**
- **Adult** (By Slow Intravenous Injection): 1000 units every 3-4 days, interval between doses to be adjusted according to response.
**Acute attacks of hereditary angioedema (under expert supervision) for Berinert**
- **Child** (By slow intravenous injection, or by intravenous infusion): 20 units/kg.
**Short-term prophylaxis of hereditary angioedema before dental, medical, or surgical procedures (under expert supervision) for Berinert**
- **Child** (By slow intravenous injection, or by intravenous infusion): 15-30 units/kg (max. per dose 1000 units) for 1 dose, to be administered less than 6 hours before procedure.
**Acute attacks of hereditary angioedema (under expert supervision) for Cinryze**
- **Child 2-11 years (body-weight 10-25 kg)** (By slow intravenous injection): 500 units for 1 dose, dose may be repeated if necessary after 60 minutes.
- **Child 2-11 years (body-weight 26 kg and above)** (By slow intravenous injection): 1000 units for 1 dose, dose may be repeated if necessary after 60 minutes.
- **Child 12-17 years** (By slow intravenous injection): 1000 units for 1 dose, dose may be repeated if necessary after 60 minutes (or sooner for patients experiencing laryngeal attacks or if treatment initiation is delayed).
**Short-term prophylaxis of hereditary angioedema before dental, medical, or surgical procedures (under expert supervision) for Cinryze**
- **Child 2-11 years (body-weight 10-25 kg)** (By slow intravenous injection): 500 units for 1 dose, to be administered up to 24 hours before procedure.
- **Child 2-11 years (body-weight 26 kg and above)** (By slow intravenous injection): 1000 units for 1 dose, to be administered up to 24 hours before procedure.
- **Child 12-17 years** (By slow intravenous injection): 1000 units for 1 dose, to be administered up to 24 hours before procedure.
**Long-term prophylaxis of severe, recurrent attacks of hereditary angioedema where acute treatment is inadequate, or when oral prophylaxis is inadequate or not tolerated (under expert supervision) for Cinryze**
- **Child 6-11 years** (By slow intravenous injection): 500 units every 3-4 days, dose and dosing interval to be adjusted according to response.
- **Child 12-17 years** (By slow intravenous injection): 1000 units every 3-4 days, interval between doses to be adjusted according to response.
Cautions
For C1-esterase inhibitor Vaccination against hepatitis A and hepatitis B may be required
Side effects
For C1-esterase inhibitor Rare or very rare Dizziness; dyspnoea; flushing; headache; hypersensitivity; hypertension; hypotension; nausea; tachycardia; thrombosis (with high doses); urticaria
Pregnancy
For C1-esterase inhibitor Manufacturer advises avoid unless essential.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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