Formulary
Brinzolamide: Indications, Dosing, Side Effects and Interactions
Brinzolamide clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Brinzolamide: Indications, Dosing, Side Effects and Interactions
Brinzolamide clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Reduction of intra-ocular pressure in ocular hypertension and open-angle glaucoma either as adjunct to beta-blockers or prostaglandin analogues or used alone in patients unresponsive to beta-blockers or if beta-blockers contra-indicated**
- **Adult** (To The Eye): Apply twice daily, then increased if necessary up to 3 times a day.
**Reduction of intra-ocular pressure in primary and secondary glaucoma either as adjunct to beta-blockers or prostaglandin analogues or used alone if unresponsive to beta-blockers or if beta-blockers contra-indicated for brinzolamide**
- **Child** (To the eye): Apply twice daily, then increased if necessary up to 3 times a day.
Cautions
Renal tubular immaturity or abnormality-risk of metabolic acidosis; systemic absorption follows topical application
Contraindications
Hyperchloraemic acidosis
Side effects
Common or very common Eye discomfort; eye disorders; taste altered; vision disorders Uncommon Arrhythmias; asthenia; cardio-respiratory distress; chest discomfort; cough; depression; diarrhoea; dizziness; dry eye; dry mouth; dyspnoea; epistaxis; eye deposit; eye inflammation; feeling abnormal; foreign body in eye; gastrointestinal discomfort; gastrointestinal disorders; headache; increased risk of infection; memory impairment; motor dysfunction; muscle complaints; nasal complaints; nausea; nervousness; oral disorders; oropharyngeal pain; pain; palpitations; renal pain; scleral discolouration; sensation abnormal; sexual dysfunction; skin reactions; sleep disorders; throat complaints; vomiting Rare or very rare Alopecia; angina pectoris; drowsiness; irritability; respiratory disorders; tinnitus Frequency not known Appetite decreased; arthralgia; asthma; hypertension; malaise; peripheral oedema; severe cutaneous adverse reactions (SCARs); tremor; urinary frequency increased; vertigo Side-effects, further information Systemic absorption can rarely cause sulfonamide-like side-effects and may require discontinuation if severe.
Interactions
**Other interactions (6):**
- AZARGA contains brinzolamide, a carbonic anhydrase inhibitor and, although administered topically, is absorbed systemically.
- There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and brinzolamide eye drops.
- The concomitant administration of eye drops containing brinzolamide and oral carbonic anhydrase inhibitors is not recommended.
- The cytochrome P-450 isozymes responsible for metabolism of brinzolamide include CYP3A4 (main), CYP2A6, CYP2B6, CYP2C8 and CYP2C9.
- It is expected that inhibitors of CYP3A4 such as ketoconazole, itraconazole, clotrimazole, ritonavir and troleandomycin will inhibit the metabolism of brinzolamide by CYP3A4.
- Brinzolamide is not an inhibitor of cytochrome P-450 isozymes.
Pregnancy
Avoid-toxicity in animal studies.
Breast feeding
Use only if benefit outweighs risk.
Hepatic impairment
Manufacturer advises avoid-no information available.
Renal impairment
Avoid if creatinine clearance less than 30 mL/minute (no information available). M See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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