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Blinatumomab [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Blinatumomab [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Blinatumomab [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Blinatumomab [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Side effects
For blinatumomab [Specialist drug] Common or very common Abdominal pain; anaemia; arrhythmias; ataxia; chest discomfort; chills; cognitive disorder; confusion; constipation; cough; cranial nerve disorder; cytokine release syndrome; decreased leucocytes; diarrhoea; dizziness; drowsiness; dyspnoea; encephalopathy; facial swelling; fever; flushing; headache; hyperbilirubinaemia; hypersensitivity; hypertension; hypogammaglobulinaemia; hypoglobulinaemia; hypotension; increased risk of infection; infusion related reaction; insomnia; leucocytosis; memory loss; nausea; neutropenia; oedema; pain; respiratory disorders; seizure; sensation abnormal; sepsis; skin reactions; speech impairment; thrombocytopenia; tremor; tumour lysis syndrome; vomiting; weight increased Uncommon Capillary leak syndrome; cytokine storm; haemophagocytic lymphohistiocytosis; lymphadenopathy; pancreatitis Frequency not known Consciousness impaired; psychiatric disorder; viral infection reactivation Side-effects, further information Cytokine release syndrome, infusion-reactions, and tumour lysis syndrome Life-threatening (including fatal) cases of cytokine release syndrome and tumour lysis syndrome have been reported in patients taking blinatumomab; temporary interruption or discontinuation might be required. Neurological events There is potentially a higher risk of neurological events in patients with clinically relevant CNS pathology. Pancreatitis Life-threatening or fatal cases of pancreatitis have been reported; temporary interruption or discontinuation might be required.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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