Formulary
Bimatoprost: Indications, Dosing, Side Effects and Interactions
Bimatoprost clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Bimatoprost: Indications, Dosing, Side Effects and Interactions
Bimatoprost clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Raised intra-ocular pressure in open-angle glaucoma,Ocular hypertension**
- **Adult** (To The Eye): Apply once daily, to be administered preferably in the evening.
Cautions
Angle-closure glaucoma (no experience of use); aphakia; asthma; chronic obstructive pulmonary disease; compromised respiratory function; congenital glaucoma (no experience of use); contact lens wearers; history of significant ocular viral infections; inflammatory ocular conditions (no experience of use); narrow-angle glaucoma (no experience of use); neovascular glaucoma (no experience of use); predisposition to bradycardia; predisposition to hypotension; pseudophakia with torn posterior lens capsule or anterior chamber lenses; risk factors for cystoid macular oedema; risk factors for iritis; risk factors for uveitis
Side effects
Common or very common Dry eye; eye discolouration; eye discomfort; eye disorders; eye inflammation; headache; hypertension; hypertrichosis; skin reactions; vision disorders Uncommon Asthenia; dizziness; madarosis; nausea; retinal haemorrhage Frequency not known Asthma; bradycardia; dyspnoea; hypotension; reactivation of infection
Interactions
**Other interactions (5):**
- No interactions are anticipated in humans, since systemic concentrations of bimatoprost are extremely low (less than 0.2 ng/ml) following ocular dosing with bimatoprost 0.3 mg/ml eye drops, solution.
- Bimatoprost is biotransformed by any of multiple enzymes and pathways, and no effects on hepatic drug metabolising enzymes were observed in preclinical studies.
- In clinical studies, bimatoprost 0.3 mg/ml, eye drops, solution was used concomitantly with a number of different ophthalmic beta-blocking agents without evidence of interactions.
- Concomitant use of bimatoprost and antiglaucomatous agents other than topical betablockers has not been evaluated during adjunctive glaucoma therapy.
- There is a potential for the IOP-lowering effect of prostaglandin analogues (e.g., bimatoprost) to be reduced in patients with glaucoma or ocular hypertension when used with other prostaglandin...
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk.
Breast feeding
Manufacturer advises avoid-present in milk in animal studies.
Hepatic impairment
Manufacturer advises use with caution in moderate-to-severe impairment-no information available.
Renal impairment
Use with caution (no information available). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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