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Betaine: Indications, Dosing, Side Effects and Interactions
Betaine clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Betaine: Indications, Dosing, Side Effects and Interactions
Betaine clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Adjunctive treatment of homocystinuria involving deficiencies or defects in cystathionine beta-synthase, 5,10-methylene-tetrahydrofolate reductase, or cobalamin cofactor metabolism (specialist use only)**
- **Adult** (By Mouth): 3 g twice daily (max. per dose 10 g), adjusted according to response; maximum 20 g per day.
**Adjunctive treatment of homocystinuria involving deficiencies or defects in cystathionine beta-synthase, 5,10-methylene-tetrahydrofolate reductase, or cobalamin cofactor metabolism (specialist use only) for betaine**
- **Neonate** (By mouth): Initially 50 mg/kg twice daily (max. per dose 75 mg/kg), adjusted according to response; maximum 150 mg/kg per day.
- **Child 1 month-9 years** (By mouth): Initially 50 mg/kg twice daily (max. per dose 75 mg/kg), adjusted according to response; maximum 150 mg/kg per day.
- **Child 10-17 years** (By mouth): 3 g twice daily (max. per dose 10 g), adjusted according to response; maximum 20 g per day.
Side effects
Abdominal discomfort; agitation; alopecia; appetite decreased; brain oedema; diarrhoea; glossitis; irritability; nausea; skin reactions; urinary incontinence; vomiting
Pregnancy
Manufacturer advises avoid unless essential-limited information available.
Breast feeding
Manufacturer advises caution-no information available.
Medicinal forms
Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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