Formulary
Berotralstat: Indications, Dosing, Side Effects and Interactions
Berotralstat is a plasma kallikrein inhibitor, which limits the production of bradykinin, a potent vasodilator associated with angioedema attacks.
MedNext Academy | 3 min read
Berotralstat: Indications, Dosing, Side Effects and Interactions
Berotralstat is a plasma kallikrein inhibitor, which limits the production of bradykinin, a potent vasodilator associated with angioedema attacks.
Drug action
Berotralstat is a plasma kallikrein inhibitor, which limits the production of bradykinin, a potent vasodilator associated with angioedema attacks.
Indications and dose
**Prevention of recurrent attacks of hereditary angioedema**
- **Adult** (By Mouth): (body-weight 40 kg and above) 150 mg once daily, dose to be taken with food.
**Prevention of recurrent attacks of hereditary angioedema for berotralstat**
- **Child 12-17 years (body-weight 40 kg and above)** (By mouth): 150 mg once daily, dose to be taken with food.
Cautions
Risk factors for QT prolongation Cautions, further information QT prolongation If treatment with berotralstat is unavoidable, monitoring is recommended-consult product literature. M
Contraindications
Body-weight less than 40 kg; not a treatment for acute attacks of angioedema-initiate individualised treatment for breakthrough attacks
Side effects
Common or very common Diarrhoea; gastrointestinal discomfort; gastrointestinal disorders; headaches; rash; vomiting Frequency not known Nausea
Pregnancy
Avoid-limited information available. M
Breast feeding
Avoid-present in milk in animal studies. M
Hepatic impairment
Avoid in moderate or severe impairment (risk of increased exposure). M
Renal impairment
Avoid in severe impairment (increased risk of prolonged QT); if treatment is unavoidable, monitoring is required-consult product literature. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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