Formulary
Bendamustine hydrochloride [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Bendamustine hydrochloride [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Bendamustine hydrochloride [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Bendamustine hydrochloride [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Chronic lymphocytic leukaemia,Non-Hodgkin's lymphoma,Multiple myeloma**
- **Adult** (By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Contraindications
For bendamustine hydrochloride [Specialist drug] Jaundice; low leucocyte count; low platelet count; major surgery less than 30 days before start of treatment; severe bone marrow suppression
Side effects
For bendamustine hydrochloride [Specialist drug] Common or very common Alopecia; amenorrhoea; anaemia; angina pectoris; appetite decreased; arrhythmias; cardiac disorder; chills; constipation; decreased leucocytes; dehydration; diarrhoea; dizziness; fatigue; fever; haemorrhage; headache; hepatitis B reactivation; hypersensitivity; hypertension; hypokalaemia; hypotension; increased risk of infection; insomnia; mucositis; nausea; neutropenia; pain; palpitations; pulmonary disorder; skin reactions; stomatitis; thrombocytopenia; tumour lysis syndrome; vomiting Uncommon Bone marrow disorders; heart failure; myocardial infarction; neoplasms; pericardial effusion Rare or very rare Anticholinergic syndrome; aphonia; ataxia; circulatory collapse; drowsiness; haemolysis; hyperhidrosis; infertility; multi organ failure; nervous system disorder; paraesthesia; peripheral neuropathy; pulmonary fibrosis; sepsis; taste altered Frequency not known Extravasation necrosis; hepatic failure; necrosis; progressive multifocal leukoencephalopathy (PML); renal failure; severe cutaneous adverse reactions (SCARs) Side-effects, further information Secondary malignancy Use of bendamustine is associated with an increased incidence of acute leukaemias. Infections Serious and fatal infections are reported, including opportunistic infections such as Pneumocystis jirovecii pneumonia (PJP), varicella zoster virus (VZV) and cytomegalovirus (CMV)-manufacturer advises monitoring for respiratory signs and symptoms throughout treatment; patients should be advised to report new signs of infection, including fever or respiratory symptoms, promptly. Reactivation of hepatitis B is reported in patients who are chronic carriers of the virus-manufacturer advises monitoring for signs and symptoms of active hepatitis B during treatment and for several months after stopping treatment.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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