Formulary
Baloxavir marboxil: Indications, Dosing, Side Effects and Interactions
Baloxavir marboxil (a pro-drug of baloxavir) reduces replication of influenza A and B viruses by inhibiting viral cap-dependent endonuclease.
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Baloxavir marboxil: Indications, Dosing, Side Effects and Interactions
Baloxavir marboxil (a pro-drug of baloxavir) reduces replication of influenza A and B viruses by inhibiting viral cap-dependent endonuclease.
Drug action
Baloxavir marboxil (a pro-drug of baloxavir) reduces replication of influenza A and B viruses by inhibiting viral cap-dependent endonuclease.
Indications and dose
**Post-exposure prophylaxis of influenza**
- **Child** (By Mouth): 12-17 years (body-weight 80 kg and above) 80 mg for 1 dose, to be taken as soon as possible within 48 hours following exposure.
- **Adult** (By Mouth): (body-weight 80 kg and above) 80 mg for 1 dose, to be taken as soon as possible within 48 hours following exposure.
**Treatment of influenza**
- **Child** (By Mouth): 12-17 years (body-weight 80 kg and above) 80 mg for 1 dose, to be taken as soon as possible within 48 hours of symptom onset.
- **Adult** (By Mouth): (body-weight 80 kg and above) 80 mg for 1 dose, to be taken as soon as possible within 48 hours of symptom onset.
**Post-exposure prophylaxis of influenza for baloxavir marboxil**
- **Child 12-17 years (body-weight up to 79 kg)** (By mouth): 40 mg for 1 dose, to be taken as soon as possible within 48 hours following exposure.
- **Child 12-17 years (body-weight 80 kg and above)** (By mouth): 80 mg for 1 dose, to be taken as soon as possible within 48 hours following exposure.
**Treatment of influenza for baloxavir marboxil**
- **Child 12-17 years (body-weight up to 79 kg)** (By mouth): 40 mg for 1 dose, to be taken as soon as possible within 48 hours of symptom onset.
- **Child 12-17 years (body-weight 80 kg and above)** (By mouth): 80 mg for 1 dose, to be taken as soon as possible within 48 hours of symptom onset.
Side effects
Uncommon Urticaria Frequency not known Angioedema
Interactions
**Other interactions (1):**
- Xofluza should not be taken with products that contain polyvalent cations such as laxatives, antacids or oral supplements containing iron, zinc, selenium, calcium or magnesium.
Pregnancy
Avoid-limited information available. M
Breast feeding
Avoid-present in milk in animal studies. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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