Formulary
Aviptadil with phentolamine mesilate: Indications, Dosing, Side Effects and Interactions
For aviptadil with phentolamine mesilate Phentolamine is a short-acting alpha-adrenoceptor antagonist that acts directly on vascular smooth muscle, resulting...
MedNext Academy | 3 min read
Aviptadil with phentolamine mesilate: Indications, Dosing, Side Effects and Interactions
For aviptadil with phentolamine mesilate Phentolamine is a short-acting alpha-adrenoceptor antagonist that acts directly on vascular smooth muscle, resulting...
Drug action
For aviptadil with phentolamine mesilate Phentolamine is a short-acting alpha-adrenoceptor antagonist that acts directly on vascular smooth muscle, resulting in vasodilatation; aviptadil is a vasoactive intestinal polypeptide that acts as a smooth muscle relaxant.
Cautions
For aviptadil with phentolamine mesilate Concomitant treatment with anticoagulants (potential increased risk of bleeding); history of psychiatric disorder or addiction (potential for abuse); severe cardiovascular disease; severe cerebrovascular disease
Contraindications
For aviptadil with phentolamine mesilate Anatomical deformation of the penis (e.g. angulation, cavernosal fibrosis, Peyronie's disease); not for use with other agents for erectile dysfunction; patients for whom sexual activity is inadvisable; penile implants; predisposition to priapism (e.g. in sickle cell anaemia or trait, multiple myeloma, or leukaemia)
Side effects
For aviptadil with phentolamine mesilate Common or very common Bruising; flushing Uncommon Dizziness; haematoma; headache; palpitations; tachycardia Rare or very rare Angina pectoris; myocardial infarction; penile fibrosis (following multiple injections); penile nodules; sexual dysfunction
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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