Formulary
Artemether with lumefantrine: Indications, Dosing, Side Effects and Interactions
Artemether with lumefantrine clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Artemether with lumefantrine: Indications, Dosing, Side Effects and Interactions
Artemether with lumefantrine clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Treatment of acute uncomplicated falciparum malaria,Treatment of chloroquine-resistant non-falciparum malaria**
- **Adult** (By Mouth): (body-weight 35 kg and above) 4 tablets for 6 doses, to be given at 0, 8, 24, 36, 48, and 60 hours (total 24 tablets over 60 hours).
**Treatment of acute uncomplicated falciparum malaria, Treatment of chloroquine-resistant non-falciparum malaria for artemether with lumefantrine**
- **Child (body-weight 5-14 kg)** (By mouth): 1 tablet for 6 doses, to be given at 0, 8, 24, 36, 48, and 60 hours (total 6 tablets over 60 hours).
- **Child (body-weight 15-24 kg)** (By mouth): 2 tablets for 6 doses, to be given at 0, 8, 24, 36, 48, and 60 hours (total 12 tablets over 60 hours).
- **Child (body-weight 25-34 kg)** (By mouth): 3 tablets for 6 doses, to be given at 0, 8, 24, 36, 48, and 60 hours (total 18 tablets over 60 hours).
- **Child (body-weight 35 kg and above)** (By mouth): 4 tablets for 6 doses, to be given at 0, 8, 24, 36, 48, and 60 hours (total 24 tablets over 60 hours).
Cautions
For artemether with lumefantrine Avoid in Acute porphyrias ; electrolyte disturbances (correct before and during treatment)
Contraindications
For artemether with lumefantrine Family history of congenital QT interval prolongation; family history of sudden death; history of arrhythmias; history of clinically relevant bradycardia; history of congestive heart failure accompanied by reduced left ventricular ejection fraction
Side effects
For artemether with lumefantrine Common or very common Abdominal pain; appetite decreased; arthralgia; asthenia; cough; diarrhoea; dizziness; gait abnormal; headache; movement disorders; myalgia; nausea; palpitations; QT interval prolongation; sensation abnormal; skin reactions; sleep disorders; vomiting Uncommon Drowsiness Frequency not known Angioedema
Pregnancy
For artemether with lumefantrine Toxicity in animal studies with artemether. Manufacturer advises use only if potential benefit outweighs risk.
Breast feeding
For artemether with lumefantrine Manufacturer advises avoid breastfeeding for at least 1 week after last dose. Present in milk in animal studies.
Hepatic impairment
For artemether with lumefantrine Manufacturer advises caution in severe impairment (no information available)-monitor ECG and plasma potassium concentration.
Renal impairment
For artemether with lumefantrine Caution in severe impairment (limited information available)-monitor ECG and plasma potassium concentration. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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