Formulary
Arsenic trioxide [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Arsenic trioxide [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Arsenic trioxide [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Arsenic trioxide [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Acute promyelocytic leukaemia**
- **Adult** (By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Side effects
For arsenic trioxide [Specialist drug] Common or very common Abdominal pain; alveolar haemorrhage; anaemia; arrhythmias; arthralgia; chest pain; chills; diarrhoea; differentiation syndrome; dizziness; dyspnoea; electrolyte imbalance; fatigue; fever; headache; hyperbilirubinaemia; hyperglycaemia; hypotension; hypoxia; increased leucocytes; increased risk of infection; ketoacidosis; myalgia; nausea; neutropenia; oedema; pain; pancytopenia; paraesthesia; pericardial effusion; QT interval prolongation; renal failure; respiratory disorders; seizure; skin reactions; thrombocytopenia; vasculitis; vision blurred; vomiting; weight increased Frequency not known Confusion; decreased leucocytes; encephalopathy; fluid imbalance; heart failure; hepatotoxicity; peripheral neuropathy; pneumonitis; sepsis Side-effects, further information Signs and symptoms of differentiation syndrome (leucocyte activation syndrome) include unexplained fever, dyspnoea, weight gain, pulmonary infiltrates, pleural or pericardial effusions, with or without leucocytosis-treat with high dose corticosteroids, consult product literature.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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