Formulary
Argatroban monohydrate: Indications, Dosing, Side Effects and Interactions
Argatroban monohydrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Argatroban monohydrate: Indications, Dosing, Side Effects and Interactions
Argatroban monohydrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
Cautions
Bleeding disorders; diabetic retinopathy; gastro-intestinal ulceration; immediately after lumbar puncture; major surgery (especially of brain, spinal cord, or eye); risk of bleeding; severe hypertension; spinal anaesthesia
Side effects
Common or very common Anaemia; haemorrhage; nausea; skin reactions Uncommon Alopecia; appetite decreased; arrhythmias; cardiac arrest; confusion; constipation; deafness; diarrhoea; dizziness; dysphagia; dyspnoea; fatigue; fever; gastritis; headache; hepatic disorders; hiccups; hyperbilirubinaemia; hyperhidrosis; hypertension; hypoglycaemia; hyponatraemia; hypotension; hypoxia; increased risk of infection; leucopenia; muscle tone decreased; muscle weakness; myalgia; myocardial infarction; pain; pericardial effusion; peripheral ischaemia; peripheral oedema; pleural effusion; renal failure; shock; speech disorder; stroke; syncope; thrombocytopenia; tongue disorder; visual impairment; vomiting; wound secretion
Interactions
**Other interactions (6):**
- Concomitant use with antiplatelet agents, thrombolytics, and other anticoagulants may increase the risk of bleeding.
- Oral anticoagulant agent s: Pharmacokinetic drug interactions between Exembol and warfarin (7.5 mg single oral dose) have not been demonstrated.
- However, the concomitant use of Exembol and warfarin (5-7.5 mg initial oral dose followed by 2.5-6 mg/day orally for 6-10 days) results in an increase of the International Normalized Ratio (INR).
- Refer to section 4.2 for recommendations for managing the switch from Exembol to oral anticoagulation.
- Thrombolytics, anti-platelet and other agents: The safety and effectiveness of Exembol with thrombolytic agents have not been established.
- As Exembol contains ethanol, an interaction with metronidazole or disulfiram cannot be excluded.
Pregnancy
Manufacturer advises avoid unless essential-limited information available.
Breast feeding
Avoid-no information available.
Hepatic impairment
Manufacturer advises caution in mild to moderate impairment-monitor aPTT; avoid in severe impairment or in patients with impairment undergoing percutaneous coronary intervention. Dose adjustments Manufacturer advises reduce initial dose to 0.5 micrograms/kg/minute in moderate impairment; adjust dose according to aPTT and as clinically indicated-consult product literature.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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