Formulary
Antithymocyte immunoglobulin (rabbit): Indications, Dosing, Side Effects and Interactions
Antithymocyte immunoglobulin (rabbit) clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Antithymocyte immunoglobulin (rabbit): Indications, Dosing, Side Effects and Interactions
Antithymocyte immunoglobulin (rabbit) clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Prophylaxis of organ rejection in heart allograft recipients**
- **Adult** (By Intravenous Infusion): 1-2.5 mg/kg daily for 3-5 days, to be given over at least 6 hours.
**Prophylaxis of organ rejection in renal allograft recipients**
- **Adult** (By Intravenous Infusion): 1-1.5 mg/kg daily for 3-9 days, to be given over at least 6 hours.
**Treatment of corticosteroid-resistant allograft rejection in renal transplantation**
- **Adult** (By Intravenous Infusion): 1.5 mg/kg daily for 7-14 days, to be given over at least 6 hours.
**Prophylaxis of organ rejection in heart allograft recipients for antithymocyte immunoglobulin (rabbit)**
- **Child** (By intravenous infusion): 1-2.5 mg/kg daily for 3-5 days, start treatment on day of transplantation, to be given over at least 6 hours.
**Prophylaxis of organ rejection in renal allograft recipients for antithymocyte immunoglobulin (rabbit)**
- **Child 1-17 years** (By intravenous infusion): 1-1.5 mg/kg daily for 3-9 days, start treatment on day of transplantation, to be given over at least 6 hours.
**Treatment of corticosteroid-resistant allograft rejection in renal transplantation for antithymocyte immunoglobulin (rabbit)**
- **Child 1-17 years** (By intravenous infusion): 1.5 mg/kg daily for 7-14 days, to be given over at least 6 hours.
Contraindications
For antithymocyte immunoglobulin (rabbit) Infection
Side effects
For antithymocyte immunoglobulin (rabbit) Common or very common Chills; diarrhoea; dysphagia; dyspnoea; fever; hypotension; infection; lymphopenia; myalgia; nausea; neoplasm malignant; neoplasms; neutropenia; reactivation of infection; secondary malignancy; sepsis; skin reactions; thrombocytopenia; vomiting Uncommon Cytokine release syndrome; hepatic disorders; hypersensitivity; infusion related reaction Side-effects, further information Tolerability is increased by pretreatment with an intravenous corticosteroid and antihistamine; an antipyretic drug such as paracetamol may also be beneficial.
Pregnancy
For antithymocyte immunoglobulin (rabbit) Manufacturer advises use only if potential benefit outweighs risk-no information available.
Breast feeding
For antithymocyte immunoglobulin (rabbit) Manufacturer advises avoid-no information available.
Medicinal forms
Solution,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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