Formulary
Amifampridine: Indications, Dosing, Side Effects and Interactions
Amifampridine clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Amifampridine: Indications, Dosing, Side Effects and Interactions
Amifampridine clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Symptomatic treatment of Lambert-Eaton myasthenic syndrome (specialist use only)**
- **Adult** (By Mouth): Initially 15 mg daily in 3 divided doses, then increased in steps of 5 mg every 4-5 days, increased to up to 60 mg daily in 3-4 divided doses (max. per dose 20 mg); maximum 60 mg per day.
Cautions
Risk factors for schwannomas
Contraindications
QT syndromes; epilepsy; uncontrolled asthma
Side effects
Common or very common Dizziness; gastrointestinal discomfort; nausea; oral disorders; peripheral coldness; sensation abnormal; sweat changes Frequency not known Anxiety; arrhythmia; asthenia; asthmatic attack; bronchial secretion increased; cough; diarrhoea; drowsiness; gastrointestinal disorder; headache; movement disorders; palpitations; Raynaud's phenomenon; seizures; sleep disorder; vision blurred
Pregnancy
Manufacturer advises avoid.
Breast feeding
Manufacturer advises avoid-no information available.
Hepatic impairment
Manufacturer advises caution (risk of increased exposure). Dose adjustments Manufacturer advises initial dose reduction to 5 mg twice daily in mild impairment, titrate in steps of 5 mg every 7 days. Manufacturer advises initial dose reduction to 5 mg once daily in moderate to severe impairment, titrate in steps of 5 mg every 7 days.
Renal impairment
Use with caution (risk of increased exposure). M Dose adjustments Reduce initial dose to 5 mg twice daily in mild impairment, titrate in steps of 5 mg every 7 days. M Reduce initial dose to 5 mg once daily in moderate to severe impairment, titrate in steps of 5 mg every 7 days. M
Medicinal forms
Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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