Formulary
Alglucosidase alfa: Indications, Dosing, Side Effects and Interactions
Alglucosidase alfa is an enzyme produced by recombinant DNA technology licensed for long-term replacement therapy in Pompe disease, a lysosomal storage...
MedNext Academy | 3 min read
Alglucosidase alfa: Indications, Dosing, Side Effects and Interactions
Alglucosidase alfa is an enzyme produced by recombinant DNA technology licensed for long-term replacement therapy in Pompe disease, a lysosomal storage...
Drug action
Alglucosidase alfa is an enzyme produced by recombinant DNA technology licensed for long-term replacement therapy in Pompe disease, a lysosomal storage disorder caused by deficiency of acid alpha-glucosidase.
Indications and dose
**Pompe disease (specialist use only)**
- **Adult** (By Intravenous Infusion): 20 mg/kg every 2 weeks.
**Pompe disease (specialist use only) for alglucosidase alfa**
- **Neonate** (By intravenous infusion): 20 mg/kg every 2 weeks.
- **Child** (By intravenous infusion): 20 mg/kg every 2 weeks.
Cautions
Cardiac dysfunction; infusion-related reactions-consult product literature; respiratory dysfunction
Side effects
Common or very common Anxiety; arrhythmias; chest discomfort; chills; cough; cyanosis; diarrhoea; dizziness; fever; flushing; hyperhidrosis; hypersensitivity; hypertension; irritability; local swelling; muscle complaints; nausea; oedema; pallor; paraesthesia; respiratory disorders; skin reactions; temperature sensation altered; throat complaints; tremor; vomiting Frequency not known Angioedema; apnoea; arthralgia; asthenia; cardiac arrest; drowsiness; dysphagia; dyspnoea; excessive tearing; eye inflammation; gastrointestinal discomfort; headache; hypotension; hypoxia; influenza like illness; infusion related reaction; malaise; musculoskeletal chest pain; nephrotic syndrome; palpitations; peripheral coldness; proteinuria; skin ulcer; vasoconstriction Side-effects, further information Infusion-related reactions are very common, calling for use of antihistamine, antipyretic, or corticosteroid; consult product literature for details.
Pregnancy
Toxicity in animal studies, but treatment should not be withheld.
Breast feeding
Manufacturer advises avoid-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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