Formulary
Albendazole: Indications, Dosing, Side Effects and Interactions
Albendazole clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Albendazole: Indications, Dosing, Side Effects and Interactions
Albendazole clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**ChronicStrongyloidesinfection**
- **Adult** (By Mouth): Chronic Strongyloides infection 400 mg twice daily for 3 days, dose may be repeated after 3 weeks if necessary.
**Hydatid disease, in conjunction with surgery to reduce the risk of recurrence or as primary treatment in inoperable cases**
- **Adult** (By Mouth): (consult product literature).
**Hookworm infections**
- **Adult** (By Mouth): 400 mg for 1 dose.
**Chronic Strongyloides infection for albendazole**
- **Child 2-17 years** (By mouth): 400 mg twice daily for 3 days, dose may be repeated after 3 weeks if necessary.
**Hydatid disease, in conjunction with surgery to reduce the risk of recurrence or as primary treatment in inoperable cases for albendazole**
- **Child 2-17 years** (By mouth): 7.5 mg/kg twice daily (max. per dose 400 mg) for 28 days followed by 14-day break, to be repeated for up to 2-3 cycles.
**Hookworm infections for albendazole**
- **Child 2-17 years** (By mouth): 400 mg for 1 dose.
Cautions
Pre-existing neurocysticercosis (may trigger neurological symptoms)
Side effects
Common or very common Abdominal pain; alopecia (reversible); dizziness; gastrointestinal disorder; hair thinning; headache; nausea; vomiting Uncommon Diarrhoea; hepatic disorders; leucopenia; skin reactions Rare or very rare Agranulocytosis; bone marrow disorders; bone pain; proteinuria; Stevens-Johnson syndrome
Interactions
**Severe interactions:**
- Possible toxicity with phenytoin on stopping primidone); stiripentol, tiagabine, valproic acid, zonisamide.
**Other interactions (3):**
- Alternative anti-convulsants may be recommended in patients treated with voriconazole or itraconazole Antihelmintics: albendazole Antineoplastics: imatinib, cyclophosphamide, lapatinib, temsirolimus...
- Teniposide) Atorvastatin Carbamezepine Ciclosporin Disopyramide Efavirenz Erythromycin Fosamprenavir Indinavir Lopinavir/ritonavir Methadone Nelfinavir Neuromuscular blocking agents (pancuronium,...
- Table 4 Drugs whose serum levels and/or effects may be altered by phenytoin Drug Classes Drugs in each Class (such as*) Antibacterial agents doxycycline rifampicin tetracycline Anticoagulants...
Pregnancy
Specialist sources indicate low risk due to poor oral bioavailability but consider avoiding during first trimester.
Breast feeding
Specialist sources indicate present in milk but amount is clinically insignificant; a single oral dose is compatible with breast-feeding.
Hepatic impairment
Caution in pre-existing liver disease (no information available). M
Medicinal forms
Tablet,Tablet,Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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