Formulary
Agalsidase alfa: Indications, Dosing, Side Effects and Interactions
Agalsidase alfa is a form of recombinant human alpha-galactosidase A used for long-term enzyme replacement therapy in Fabry's disease.
MedNext Academy | 3 min read
Agalsidase alfa: Indications, Dosing, Side Effects and Interactions
Agalsidase alfa is a form of recombinant human alpha-galactosidase A used for long-term enzyme replacement therapy in Fabry's disease.
Drug action
Agalsidase alfa is a form of recombinant human alpha-galactosidase A used for long-term enzyme replacement therapy in Fabry's disease.
Indications and dose
**Fabry's disease (under expert supervision)**
- **Adult** (By Intravenous Infusion): 200 micrograms/kg every 2 weeks.
**Fabry's disease (under expert supervision) for agalsidase alfa**
- **Child 7-17 years** (By intravenous infusion): 200 micrograms/kg every 2 weeks.
Side effects
Common or very common Arrhythmias; asthenia; chest discomfort; chills; cough; diarrhoea; dizziness; dyspnoea; excessive tearing; fever; flushing; gastrointestinal discomfort; headache; hoarseness; hypersomnia; hypertension; increased risk of infection; influenza like illness; joint disorders; malaise; musculoskeletal discomfort; myalgia; nausea; ototoxicity; pain; palpitations; peripheral oedema; peripheral swelling; rhinorrhoea; sensation abnormal; skin reactions; taste altered; temperature sensation altered; throat complaints; tremor; vomiting Uncommon Altered smell sensation; angioedema; hypersensitivity; sensation of pressure Frequency not known Heart failure; hyperhidrosis; hypotension; myocardial ischaemia Side-effects, further information Infusion-related reactions; manage by interrupting the infusion, or minimise by pre-treatment with an antihistamine or corticosteroid - consult product literature.
Interactions
**Other interactions (2):**
- Replagal should not be co-administered with chloroquine, amiodarone, benoquin or gentamicin since these substances have the potential to inhibit intra-cellular -galactosidase activity.
- In clinical studies, neuropathic pain medicinal products (such as carbamazepine, phenytoin and gabapentin) were administered concurrently to most patients without any evidence of interaction.
Pregnancy
Use with caution.
Breast feeding
Use with caution-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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