Formulary
Aflibercept [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Aflibercept [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Aflibercept [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Aflibercept [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Colorectal cancer**
- **Adult** (By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Contraindications
For aflibercept [Specialist drug] With intravenous use Moderate or severe congestive heart failure; uncontrolled hypertension With intravitreal use Clinical signs of irreversible ischaemic visual function loss; ocular or periocular infection; severe intra-ocular inflammation
Side effects
For aflibercept [Specialist drug] General side-effects: Common or very common Haemorrhage Specific side-effects: Common or very common With intravenous use Appetite decreased; asthenic conditions; dehydration; diarrhoea; dysphonia; dyspnoea; embolism and thrombosis; fistula (discontinue); gastrointestinal discomfort; gastrointestinal disorders; headache; hypersensitivity; hypertension; increased risk of infection; leucopenia; neutropenia; neutropenic sepsis; oral disorders; oropharyngeal pain; proteinuria; rhinorrhoea; skin reactions; thrombocytopenia; weight decreased With intravitreal use Cataract; eye discomfort; eye disorders; eye inflammation; retinal pigment epithelial tear; vision disorders Uncommon With intravenous use Gastrointestinal perforation (discontinue); healing impaired; heart failure (discontinue); nephrotic syndrome; osteonecrosis of jaw; posterior reversible encephalopathy syndrome (PRES); thrombotic microangiopathy With intravitreal use Lens opacity Frequency not known With intravenous use Alopecia; anaemia; anastomotic leak; aneurysm; angina pectoris; artery dissection; cerebrovascular insufficiency; constipation; hyperbilirubinaemia; myocardial infarction; nausea; vomiting; wound dehiscence Side-effects, further information Intravenous use Can impair wound healing-discontinue if wound healing complications requiring medical intervention occur. Haemorrhage, including fatal cases, have been reported. Intravitreal use Discontinue treatment in the event of retinal break, rhegmatogenous retinal detachment, or if stage 3 or 4 macular holes develop.
Medicinal forms
Solution,Solution,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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