Formulary
Treprostinil: Indications, Dosing, Side Effects and Interactions
Treprostinil is a prostacyclin analogue that has a direct vasodilation effect on the pulmonary and systemic arterial circulation and inhibits platelet...
MedNext Academy | 3 min read
Treprostinil: Indications, Dosing, Side Effects and Interactions
Treprostinil is a prostacyclin analogue that has a direct vasodilation effect on the pulmonary and systemic arterial circulation and inhibits platelet...
Drug action
Treprostinil is a prostacyclin analogue that has a direct vasodilation effect on the pulmonary and systemic arterial circulation and inhibits platelet aggregation.
Cautions
Avoid abrupt withdrawal or sudden marked dose reductions (risk of rebound pulmonary hypertension); BMI greater than 30 kg/m 2 (slower clearance); elderly (limited information available); systolic blood pressure below 85 mmHg (increased risk of systemic hypotension)
Contraindications
Bleeding, such as active gastro-intestinal ulcer, intracranial haemorrhage, or injury; cerebrovascular event (within the last 3 months); congenital or acquired valvular defects with myocardial function disorders (not related to pulmonary hypertension); congestive heart failure due to severe left ventricular dysfunction; decompensated cardiac failure (unless under close medical supervision); myocardial infarction (within the last 6 months); pulmonary arterial hypertension caused by veno-occlusive disease; severe arrhythmias; severe coronary heart disease; unstable angina
Side effects
Common or very common Arthralgia; diarrhoea; dizziness; haemorrhage; headache; hypotension; myalgia; nausea; oedema; pain; skin reactions; vasodilation; vomiting Frequency not known Cardiac failure high output; catheter related infection; increased risk of infection; sepsis; thrombocytopenia; thrombophlebitis
Pregnancy
Use only if potential benefit outweighs risk-limited information available. M
Breast feeding
Discontinue breast-feeding-no information available. M
Hepatic impairment
Caution in mild to moderate impairment; avoid in severe impairment (risk of increased exposure). M Dose adjustments Dose reduction (risk of increased exposure)-consult product literature. M
Renal impairment
Caution (risk of increased exposure). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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