Formulary
Tiaprofenic acid: Indications, Dosing, Side Effects and Interactions
Tiaprofenic acid clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Tiaprofenic acid: Indications, Dosing, Side Effects and Interactions
Tiaprofenic acid clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Pain and inflammation in rheumatic disease and other musculoskeletal disorders**
- **Adult** (By Mouth): 300 mg twice daily.
Cautions
Allergic disorders; cardiac impairment (NSAIDs may impair renal function); cerebrovascular disease; coagulation defects; connective-tissue disorders; dehydration (risk of renal impairment); elderly (risk of serious side-effects and fatalities); heart failure; history of gastro-intestinal disorders (e.g. ulcerative colitis, Crohn's disease); ischaemic heart disease; may mask symptoms of infection; peripheral arterial disease; risk factors for cardiovascular events; uncontrolled hypertension
Contraindications
Active bladder disease (or symptoms); active gastro-intestinal bleeding; active gastro-intestinal ulceration; active prostate disease (or symptoms); history of gastro-intestinal bleeding related to previous NSAID therapy; history of gastro-intestinal perforation related to previous NSAID therapy; history of recurrent gastro-intestinal haemorrhage (two or more distinct episodes); history of recurrent gastro-intestinal ulceration (two or more distinct episodes); history of recurrent urinary-tract disorders (if urinary symptoms develop discontinue immediately and perform urine tests and culture); severe heart failure
Side effects
Frequency not known Agranulocytosis; alopecia; anaemia; angioedema; aplastic anaemia; appetite decreased; asthma; bladder pain; bronchospasm; confusion; constipation; Crohn's disease aggravated; cystitis; depression; diarrhoea; dizziness; drowsiness; dyspnoea; fatigue; fertility decreased female; fluid retention; gastrointestinal discomfort; gastrointestinal disorders; haemolytic anaemia; haemorrhage; hallucination; headache; heart failure; hepatic disorders; hypersensitivity; hypertension; increased risk of arterial thromboembolism; malaise; meningitis aseptic (patients with connective-tissue disorders such as systemic lupus erythematosus may be especially susceptible); nausea; nephritis tubulointerstitial; nephropathy; neutropenia; oedema; optic neuritis; oral ulceration; pancreatitis; paraesthesia; photosensitivity reaction; renal failure (more common in patients with pre-existing renal impairment); severe cutaneous adverse reactions (SCARs); skin reactions; sodium retention; thrombocytopenia; tinnitus; urinary disorders; urinary tract inflammation; vertigo; visual impairment; vomiting Side-effects, further information For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non-steroidal anti-inflammatory drugs
Pregnancy
Important safety information For tiaprofenic acid CSM advice Following reports of severe cystitis the CSM has recommended that tiaprofenic acid should not be given to patients with urinary-tract disorders and should be stopped if urinary symptoms develop. Patients should be advised to stop taking tiaprofenic acid and to report to their doctor promptly if they develop urinary-tract symptoms (such as increased frequency, nocturia, urgency, pain on urinating, or blood in urine). MHRA/CHM advice: NSAIDs: potential risks following prolonged use after 20 weeks of pregnancy (June 2023) See Non-steroidal anti-inflammatory drugs .
Breast feeding
Use with caution during breast-feeding. Amount too small to be harmful.
Hepatic impairment
Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment. Dose adjustments In elderly patients, manufacturer advises dose reduction to 200 mg twice daily in mild to moderate impairment.
Renal impairment
In general, for NSAIDs the MHRA advises to avoid where possible; if necessary, use with caution (risk of fluid retention and further renal impairment, including renal failure). For tiaprofenic acid , avoid in severe impairment. M Dose adjustments In elderly patients, reduce dose to 200 mg twice daily in mild to moderate impairment. M
Medicinal forms
Medicinal forms No licensed medicines listed.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Tiaprofenic acid in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

