Formulary
Pomalidomide [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Pomalidomide [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Pomalidomide [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Pomalidomide [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Multiple myeloma**
- **Adult** (By Mouth): Specialist drug - access specialist resources for dosing information.
Side effects
For pomalidomide [Specialist drug] Common or very common Anaemia; angioedema; appetite decreased; atrial fibrillation; cataract; Clostridioides difficile colitis; confusion; constipation; cough; decreased leucocytes; depression; diarrhoea; dizziness; dry mouth; dyspnoea; electrolyte imbalance; embolism and thrombosis; fall; fatigue; fever; gastrointestinal discomfort; haemorrhage; heart failure; hyperglycaemia; hypertension; hyperuricaemia; hypotension; increased risk of infection; insomnia; interstitial lung disease; intracranial haemorrhage; level of consciousness decreased; muscle spasms; muscle weakness; myocardial infarction; nausea; neoplasms; neutropenia; oedema; pain; pancytopenia; paraesthesia; pelvic pain; peripheral neuropathy; renal impairment; sepsis; skin reactions; stomatitis; syncope; taste altered; thrombocytopenia; tremor; urinary retention; vertigo; vomiting; weight decreased Uncommon Hepatitis; hyperbilirubinaemia; stroke; tumour lysis syndrome Frequency not known Hepatitis B reactivation; severe cutaneous adverse reactions (SCARs)
Pregnancy
Important safety information For pomalidomide [Specialist drug] MHRA/CHM advice: Risk of hepatitis B reactivation (May 2016) An EU wide review has concluded that pomalidomide can cause hepatitis B reactivation; the MHRA recommends to establish hepatitis B virus status in all patients before initiation of treatment. Patients with a history of hepatitis B infection should be closely monitored for signs and symptoms of active infection throughout treatment; expert advice should be sought for patients who test positive for active infection. Pregnancy Prevention Programme Important: teratogenic risk . Patients, prescribers, and pharmacists must comply with the manufacturer's Pregnancy Prevention Programme. Every prescription must be accompanied by a completed Prescription Authorisation Form. For females of childbearing potential, each prescription for pomalidomide should be limited to a maximum supply of 4 weeks' treatment. Pregnancy testing should ideally be carried out on the same day as prescription issuing and dispensing. MHRA/CHM advice: Immunomodulatory drugs and pregnancy prevention: temporary advice for management during coronavirus (COVID-19) (May 2020) The MHRA has issued temporary guidance for female patients on pomalidomide during the coronavirus (COVID-19) pandemic to support adherence to the Pregnancy Prevention Programme (see Conception and contraception ), particularly for those who are shielding due to other health conditions, and should be followed until further notice. Thromboembolism Risk factors for thromboembolism (such as smoking, hypertension, hyperlipidaemia) should be minimised. Thromboprophylaxis should be considered, particularly in patients with additional risk factors. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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