Formulary
Frovatriptan: Indications, Dosing, Side Effects and Interactions
Frovatriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Frovatriptan: Indications, Dosing, Side Effects and Interactions
Frovatriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Treatment of acute migraine**
- **Adult** (By Mouth): 2.5 mg, dose to be taken as soon as possible after onset, followed by 2.5 mg after 2 hours if required, dose to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); maximum 5 mg per day.
**Menstrual migraine prophylaxis**
- **Adult** (By Mouth): 2.5 mg twice daily, to be taken from 2 days before until 3 days after bleeding starts.
Cautions
Conditions which predispose to coronary artery disease; elderly
Contraindications
Coronary vasospasm; ischaemic heart disease; peripheral vascular disease; previous cerebrovascular accident; previous myocardial infarction; previous transient ischaemic attack; Prinzmetal's angina; severe hypertension; uncontrolled hypertension
Side effects
Common or very common Asthenia; chest discomfort; dizziness; drowsiness; dry mouth; flushing; gastrointestinal discomfort; headache; hyperhidrosis; nausea; sensation abnormal; throat complaints; vision disorders Uncommon Anxiety; arrhythmias; arthralgia; concentration impaired; confusion; dehydration; depression; diarrhoea; dysphagia; ear discomfort; eye discomfort; gastrointestinal disorders; hypertension; increased risk of infection; malaise; musculoskeletal stiffness; neuromuscular dysfunction; pain; palpitations; peripheral coldness; psychiatric disorders; skin reactions; sleep disorders; taste altered; temperature sensation altered; thirst; tinnitus; tremor; urinary disorders; vertigo Rare or very rare Breast tenderness; burping; constipation; ear disorder; epistaxis; fever; hiccups; hyperacusia; hypoglycaemia; irritable bowel syndrome; lymphadenopathy; memory loss; movement disorder; oesophageal spasm; oral disorders; piloerection; reflexes decreased; renal pain; respiratory disorders; self mutilation Frequency not known Angioedema; coronary vasospasm; hypersensitivity; myocardial infarction Side-effects, further information Discontinue if symptoms of heat, heaviness, pressure or tightness (including throat and chest) occur.
Pregnancy
There is limited experience of using 5HT 1 -receptor agonists during pregnancy; manufacturers advise that they should be avoided unless the potential benefit outweighs the risk.
Breast feeding
Present in milk in animal studies-withhold breast-feeding for 24 hours.
Hepatic impairment
Manufacturer advises avoid in severe impairment-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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