Formulary
Eravacycline: Indications, Dosing, Side Effects and Interactions
Eravacycline clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Eravacycline: Indications, Dosing, Side Effects and Interactions
Eravacycline clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Complicated intra-abdominal infections**
- **Adult** (By Intravenous Infusion): 1 mg/kg every 12 hours for 4-14 days.
Cautions
Myasthenia gravis (muscle weakness may be increased); systemic lupus erythematosus (may be exacerbated)
Side effects
Common or very common Angioedema; diarrhoea; headache; Henoch-Schnlein purpura; hypersensitivity; nausea; pericarditis; photosensitivity reaction; skin reactions; systemic lupus erythematosus exacerbated; vomiting Uncommon Dizziness; pancreatitis Rare or very rare Appetite decreased; discolouration of thyroid gland; dysphagia; eosinophilia; fontanelle bulging (in infants); gastrointestinal disorders; glossitis; haemolytic anaemia; hepatic disorders; idiopathic intracranial hypertension; increased risk of infection; neutropenia; pseudomembranous enterocolitis; Stevens-Johnson syndrome; thrombocytopenia Frequency not known Tooth discolouration Side-effects, further information Headache and visual disturbances may indicate benign intracranial hypertension (discontinue treatment if raised intracranial pressure develops). Side-effects For eravacycline Common or very common Thrombophlebitis Uncommon Hyperbilirubinaemia; hyperhidrosis
Interactions
**Severe interactions:**
- The increased exposure is not likely to be clinically significant; thus, no dose adjustment is required when eravacycline is co-administered with CYP3A inhibitors.
- However, patients receiving strong CYP3A inhibitors (for example ritonavir, itraconazole, clarithromycin) with a combination of factors that may increase the exposure, such as severe hepatic...
**Other interactions (6):**
- Potential for other medicinal products to affect the pharmacokinetics of eravacycline Concomitant administration of the strong CYP 3A4/3A5 inducer rifampicin altered the pharmacokinetics of...
- The eravacycline dose should be increased by approximately 50% (1.5 mg/kg intravenous q12h) when co-administered with rifampicin or other strong CYP3A inducers such as phenobarbital, carbamazepine,...
- Concomitant administration of the strong CYP3A inhibitor itraconazole altered the pharmacokinetics of eravacycline, increasing C max by approximately 5% and AUC 024 by approximately 23%, and...
- In vitro , eravacycline was shown to be a substrate for the transporters P-gp, OATP1B1 and OATP1B3.
- A drug-drug interaction in vivo cannot be excluded and co-administration of eravacycline and other medicinal products that inhibit these transporters (examples of OATP1B1/3 inhibitors; atazanavir,...
- Potential for eravacycline to affect the pharmacokinetics of other medicinal products In vitro , eravacycline and its metabolites are not inhibitors or inducers of CYP enzymes or transport proteins...
Pregnancy
Should not be given to pregnant women; effects on skeletal development have been documented in the first trimester in animal studies. Administration during the second or third trimester may cause discoloration of the child's teeth, and maternal hepatotoxicity has been reported with large parenteral doses.
Breast feeding
Should not be given to women who are breast-feeding (although absorption and therefore discoloration of teeth in the infant is probably usually prevented by chelation with calcium in milk).
Hepatic impairment
In general, manufacturers advise caution. Hepatic impairment For eravacycline Caution in severe impairment (increased risk of exposure). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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