Formulary
Ceftobiprole: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
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Ceftobiprole: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Drug action
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Indications and dose
**Hospital-acquired pneumonia (excluding ventilator-associated pneumonia),Community-acquired pneumonia**
- **Adult** (By Intravenous Infusion): 500 mg every 8 hours.
Cautions
Pre-existing seizure disorder-increased risk of seizures; supra-normal creatinine clearance Cautions, further information Supra-normal creatinine clearance Manufacturer advises to measure baseline renal function and increase duration of infusion if creatinine clearance greater than 150 mL/minute.
Side effects
Common or very common Abdominal pain; diarrhoea; dizziness; eosinophilia; headache; leucopenia; nausea; neutropenia; pseudomembranous enterocolitis; skin reactions; thrombocytopenia; vomiting Uncommon Anaphylactic reaction; angioedema Rare or very rare Agranulocytosis; haemolytic anaemia; nephritis tubulointerstitial (reversible); severe cutaneous adverse reactions (SCARs) Side-effects For ceftobiprole Common or very common Drowsiness; dyspepsia; electrolyte imbalance; hypersensitivity; increased risk of infection; taste altered Uncommon Anaemia; anxiety; asthma; Clostridioides difficile colitis; dyspnoea; laryngeal pain; muscle spasms; peripheral oedema; renal failure; sleep disorders; thrombocytosis Frequency not known Antibiotic associated colitis; seizure
Pregnancy
Manufacturer advises avoid unless essential-no information available.
Breast feeding
Manufacturer advises avoid-present in milk in animal studies.
Renal impairment
Use with caution in severe impairment (risk of increased exposure, limited information available). M Dose adjustments Reduce dose to 500 mg every 12 hours in moderate impairment, and 250 mg every 12 hours in severe impairment. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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