Formulary
Calcifediol monohydrate: Indications, Dosing, Side Effects and Interactions
Calcifediol monohydrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Calcifediol monohydrate: Indications, Dosing, Side Effects and Interactions
Calcifediol monohydrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Primary prevention of vitamin D deficiency**
- **Adult** (By Mouth): 266 micrograms once a month.
**Treatment of vitamin D deficiency**
- **Adult** (By Mouth): 266 micrograms once a month, increased if necessary up to 266 micrograms once weekly, dose to be adjusted according to plasma-25-hydroxyvitamin D concentration; maintenance 266 micrograms once a month.
Cautions
Granulomatous diseases (risk of increased sensitivity to vitamin D); heart failure; nephrolithiasis; prolonged immobilisation (risk of hypercalcaemia-consider reducing dose) Cautions, further information Heart failure Risk of hypercalcaemia and arrhythmias-monitor plasma-calcium concentration twice a week at start of treatment. M
Contraindications
D and analogues (systemic) Hypercalcaemia; metastatic calcification
Side effects
D and analogues (systemic) Common or very common Abdominal pain; headache; hypercalcaemia; hypercalciuria; nausea; skin reactions Uncommon Appetite decreased; arrhythmia; asthenia; constipation; diarrhoea; dry mouth; myalgia; vomiting; weight decreased Overdose Symptoms of overdosage include anorexia, lassitude, nausea and vomiting, diarrhoea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and raised concentrations of calcium and phosphate in plasma and urine. Side-effects For calcifediol monohydrate Rare or very rare Conjunctivitis (with very high doses); corneal calcification (with very high doses); photophobia (with very high doses) Frequency not known Abdominal cramps; albuminuria; hypercholesterolaemia; soft tissue calcification; taste altered
Interactions
**Other interactions (5):**
- - Phenytoin, phenobarbital, primidone and other enzyme inducers: enzyme inducers may reduce plasma concentrations of calcifediol monohydrate and inhibit its effects by inducing its hepatic metabolism.
- For this reason, it is generally recommended to monitor plasma 25-OH-D levels when calcifediol monohydrate is administered with antiepileptics that are CYP3A4 inducers in order to consider...
- Using other types of laxatives or at least spacing doses is recommended.
- The dosage of agents that bind to phosphate shall be adjusted according to phosphate concentrations in serum.
- It is recommended to take vitamin D two hours before, or four hours after antacids.
Pregnancy
D and analogues (systemic) High doses teratogenic in animals but therapeutic doses unlikely to be harmful.
Breast feeding
D and analogues (systemic) Caution with high doses; may cause hypercalcaemia in infant-monitor serum-calcium concentration.
Renal impairment
Caution in mild to moderate impairment (risk of reduced efficacy-monitor plasma-calcium and plasma-phosphate concentration); avoid in severe impairment. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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