Formulary
Aceclofenac: Indications, Dosing, Side Effects and Interactions
Aceclofenac clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Aceclofenac: Indications, Dosing, Side Effects and Interactions
Aceclofenac clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis**
- **Adult** (By Mouth): 100 mg twice daily.
Cautions
Allergic disorders; avoid in Acute porphyrias ; cardiac impairment (NSAIDs may impair renal function); connective-tissue disorders; dehydration (risk of renal impairment); elderly (risk of serious side-effects and fatalities); history of cardiac failure; history of cerebrovascular bleeding; history of gastro-intestinal disorders (e.g. ulcerative colitis, Crohn's disease); hypertension; may mask symptoms of infection; oedema; risk factors for cardiovascular events
Contraindications
Active bleeding; active gastro-intestinal bleeding; active gastro-intestinal ulceration; bleeding disorders; cerebrovascular disease; history of gastro-intestinal bleeding related to previous NSAID therapy; history of gastro-intestinal perforation related to previous NSAID therapy; history of recurrent gastro-intestinal haemorrhage (two or more distinct episodes); history of recurrent gastro-intestinal ulceration (two or more distinct episodes); ischaemic heart disease; mild to severe heart failure; peripheral arterial disease; varicella infection
Side effects
Common or very common Diarrhoea; dizziness; gastrointestinal discomfort; nausea Uncommon Constipation; gastrointestinal disorders; oral disorders; skin reactions; vomiting Rare or very rare Anaemia; angioedema; bone marrow disorders; depression; drowsiness; dyspnoea; fatigue; haemolytic anaemia; haemorrhage; headache; heart failure; hepatic disorders; hyperkalaemia; hypersensitivity; hypertension; inflammatory bowel disease; leg cramps; nephrotic syndrome; neutropenia; oedema; palpitations; pancreatitis; paraesthesia; renal failure (more common in patients with pre-existing renal impairment); respiratory disorders; severe cutaneous adverse reactions (SCARs); sleep disorders; taste altered; thrombocytopenia; tinnitus; tremor; vasculitis; vasodilation; vertigo; visual impairment; weight increased Frequency not known Acute coronary syndrome; agranulocytosis; asthma; confusion; hallucination; increased risk of arterial thromboembolism; increased risk of ischaemic stroke; malaise; meningitis aseptic (patients with connective-tissue disorders such as systemic lupus erythematosus may be especially susceptible); nephritis tubulointerstitial; optic neuritis; photosensitivity reaction; platelet aggregation inhibition; respiratory tract reaction Side-effects, further information For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non-steroidal anti-inflammatory drugs
Interactions
**Other interactions (20):**
- Other analgesics including cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs (including aspirin) as this may increase the risk of adverse effects, including GI...
- Diuretics: Reduced diuretic effect.
- Diuretics can increase the risk of nephrotoxicity of NSAIDs.
- Although it was not shown to affect blood pressure control when co-administered with bendrofluazide, interactions with other diuretics cannot be ruled out.
- When concomitant administration with potassium-sparing diuretics is employed, serum potassium should be monitored.
- Cardiac glycosides like digoxin:: NSAIDs may exacerbate cardiac failure, reduce GFR (glomerular filtration rate) and increase plasma glycoside levels.
Pregnancy
Important safety information For aceclofenac MHRA/CHM advice: NSAIDs: potential risks following prolonged use after 20 weeks of pregnancy (June 2023) See Non-steroidal anti-inflammatory drugs .
Breast feeding
Use with caution during breast-feeding. Manufacturer advises avoid.
Hepatic impairment
Manufacturer advises caution in mild to moderate impairment; avoid in hepatic failure. Dose adjustments Manufacturer advises consider initial dose reduction to 100 mg daily in mild to moderate impairment.
Renal impairment
In general, for NSAIDs the MHRA advises to avoid where possible; if necessary, use with caution (risk of fluid retention and further renal impairment, including renal failure). For aceclofenac , avoid in renal failure. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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